Founded in 1947, Zhujiang Hospital, Southern Medical University is the Second Affiliated Hospital of Southern Medical University, a large comprehensive Grade-A tertiary hospital integrating medical care, teaching, research, and preventive health care. Located in the Haizhu District of Guangzhou on the south bank of the Pearl River, it is a national "Baby-Friendly Hospital" and a key construction unit of Guangdong Province's high-level hospitals. The hospital has distinctive strengths in neurosurgery, hepatobiliary and pancreatic surgery, and pediatrics; its neurosurgery department is a national key clinical specialty renowned across South China.

Founded in 1903, the First Affiliated Hospital of Guangzhou Medical University is a large Grade-A tertiary hospital and the host institution of the Guangzhou Institute of Respiratory Health and the National Center for Respiratory Medicine. Its Respiratory and Critical Care Medicine Department has ranked first nationally in the Fudan version of the China Hospital Rankings for many consecutive years, and the hospital is internationally advanced in chronic airway diseases, respiratory infections, early diagnosis and treatment of lung cancer, and interventional pulmonology. The hospital excelled in major public health missions including the fight against SARS and COVID-19, and its respiratory team was awarded the national honor "Medal of the Republic." Located in central Guangzhou, the hospital offers multilingual service windows and fast-track channels for patients from home and abroad.

Founded in 1965, the Zhongshan Ophthalmic Center, Sun Yat-sen University is the only ophthalmic specialty institution directly under the National Health Commission and the oldest and largest eye hospital in China. As the country's sole national ophthalmic center integrating eye care, teaching, research, and blindness prevention, its comprehensive strength has ranked first in ophthalmology in the Fudan version of the China Hospital Rankings for many consecutive years. The Center is internationally leading in cataracts, glaucoma, corneal disease, fundus disease, ocular tumors, and myopia correction, attracting a large number of patients with complex ophthalmic conditions from around the world each year.

Founded in 1974, the Hospital of Stomatology, Sun Yat-sen University (Guangdong Provincial Stomatological Hospital) is a Grade-A tertiary stomatology specialty hospital administered by the National Health Commission and the lead unit in building the National Stomatology Regional Medical Center (South China). The hospital integrates oral medical care, teaching, research, and prevention, with specialties including oral and maxillofacial surgery, dental implants, and orthodontics ranking among the top in China. It represents the highest level of stomatology education and clinical practice in South China.

Founded in 1944, the Guangdong Provincial Maternal and Child Health Hospital (Guangdong Provincial Children's Hospital, Guangdong Provincial Obstetrics and Gynecology Hospital) is a Grade-A tertiary maternal and child health hospital directly under the Guangdong Provincial Health Commission, and is among the first batch of national-level demonstration bases for early childhood development and a national key specialty construction unit for pregnancy and childbirth care designated by the National Health Commission. As an important maternal and child health center in South China, the hospital has strong departments in obstetrics, pediatrics, neonatology, and assisted reproduction, with delivery volume consistently ranking among the top in the province for many years.

The Guangzhou Women and Children's Medical Center (Guangzhou Medical University) is the largest Grade-A tertiary women and children's specialty hospital in South China and among the first batch of public children's hospitals in China to receive JCI accreditation. The center operates multiple campuses including Zhujiang New Town, Children's Campus, and Maternal and Infant Campus, with annual outpatient volume ranking among the top women and children's specialty hospitals in the country. Its departments of obstetrics, pediatrics, neonatal surgery, pediatric hematology and oncology, and reproductive medicine are nationally leading, and the center has an international department providing internationalized, high-quality care for patients at home and abroad.

Founded in 1933, the Guangdong Provincial Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Guangzhou University of Chinese Medicine) is one of the earliest TCM hospitals in China's modern history, a Grade-A tertiary TCM hospital, and the largest TCM hospital in the country. Integrating medical care, teaching, research, and preventive health, the hospital is nationally leading in integrated Chinese and Western medicine with distinct TCM strengths, and houses specialized departments including rehabilitation medicine and a preventive health (Zhi Wei Bing) center. Its comprehensive strength has ranked among the top TCM hospitals in China for many consecutive years, with the highest annual outpatient volume among national TCM hospitals, and its rehabilitation medicine, acupuncture, and traumatology departments are renowned at home and abroad.

Founded in 2001, Clifford Hospital, Guangdong (Clifford Hospital Affiliated with Jinan University) is the first comprehensive Grade-A tertiary hospital in China integrating traditional Chinese and Western medicine to receive international JCI accreditation, and a designated hospital for foreign-related medical services. Located in Clifford Estates, Panyu District, Guangzhou, the hospital integrates medical care, teaching, research, and preventive health, and has an international diagnosis and treatment center providing high-quality international medical services for compatriots from Hong Kong, Macao, Taiwan, and foreign visitors. Its oncology, gynecology, obstetrics, and cardiology departments are particularly strong, and its health screening services are very popular.