Founded in 1974, the Hospital of Stomatology, Sun Yat-sen University (Guangdong Provincial Stomatological Hospital) is a Grade-A tertiary stomatology specialty hospital administered by the National Health Commission and the lead unit in building the National Stomatology Regional Medical Center (South China). The hospital integrates oral medical care, teaching, research, and prevention, with specialties including oral and maxillofacial surgery, dental implants, and orthodontics ranking among the top in China. It represents the highest level of stomatology education and clinical practice in South China.

Founded in 1965, the Zhongshan Ophthalmic Center, Sun Yat-sen University is the only ophthalmic specialty institution directly under the National Health Commission and the oldest and largest eye hospital in China. As the country's sole national ophthalmic center integrating eye care, teaching, research, and blindness prevention, its comprehensive strength has ranked first in ophthalmology in the Fudan version of the China Hospital Rankings for many consecutive years. The Center is internationally leading in cataracts, glaucoma, corneal disease, fundus disease, ocular tumors, and myopia correction, attracting a large number of patients with complex ophthalmic conditions from around the world each year.

Founded in 1903, the First Affiliated Hospital of Guangzhou Medical University is a large Grade-A tertiary hospital and the host institution of the Guangzhou Institute of Respiratory Health and the National Center for Respiratory Medicine. Its Respiratory and Critical Care Medicine Department has ranked first nationally in the Fudan version of the China Hospital Rankings for many consecutive years, and the hospital is internationally advanced in chronic airway diseases, respiratory infections, early diagnosis and treatment of lung cancer, and interventional pulmonology. The hospital excelled in major public health missions including the fight against SARS and COVID-19, and its respiratory team was awarded the national honor "Medal of the Republic." Located in central Guangzhou, the hospital offers multilingual service windows and fast-track channels for patients from home and abroad.

Founded in 1950, Zhuhai People's Hospital (Jinan University Zhuhai Clinical Medical College) is the oldest and largest municipal public Grade-A tertiary comprehensive hospital in Zhuhai. As the city's medical center, the hospital undertakes the city's primary medical, teaching, research, and emergency public health response tasks, and is a non-directly-affiliated hospital of Jinan University. Located in Zhuhai, a key node city of the Guangdong-Hong Kong-Macao Greater Bay Area and just across the water from Macao, the hospital enjoys a unique geographical advantage in serving residents of Zhuhai and Macao, with its critical care medicine, orthopedics, and cardiovascular medicine departments wielding significant regional influence.

Founded in 1947, Zhujiang Hospital, Southern Medical University is the Second Affiliated Hospital of Southern Medical University, a large comprehensive Grade-A tertiary hospital integrating medical care, teaching, research, and preventive health care. Located in the Haizhu District of Guangzhou on the south bank of the Pearl River, it is a national "Baby-Friendly Hospital" and a key construction unit of Guangdong Province's high-level hospitals. The hospital has distinctive strengths in neurosurgery, hepatobiliary and pancreatic surgery, and pediatrics; its neurosurgery department is a national key clinical specialty renowned across South China.

Founded in 1941, Nanfang Hospital, Southern Medical University is a modern large comprehensive Grade-A tertiary hospital integrating medical care, teaching, and research. As an important medical, educational, and research base in South China, the hospital has 16 national key clinical specialties. Its international medical services started early and have a mature system; the Huiqiao Building International Medical Center is one of the earliest international medical centers established in China, providing high-quality medical services aligned with international standards for expatriates and compatriots from Hong Kong, Macao, and Taiwan.

Established in 1964, the Sixth Affiliated Hospital, Sun Yat-sen University is a large comprehensive Grade-A tertiary hospital with distinctive strengths in digestive system diseases. The hospital houses the largest gastroenterology and anorectal specialty in China, and its comprehensive diagnosis and treatment of gastrointestinal tumors is nationally leading and internationally renowned. As the center for digestive disease diagnosis and treatment in South China and the Guangdong Provincial Institute of Gastroenterology, the hospital ranks among the top in China in the scale and technical level of diagnosis and treatment of colorectal cancer, inflammatory bowel disease, and gastroesophageal diseases.

The Fifth Affiliated Hospital, Sun Yat-sen University is located in Zhuhai, a gateway hub city of the Guangdong-Hong Kong-Macao Greater Bay Area, in close proximity to Hong Kong and Macao. It is a large comprehensive Grade-A tertiary hospital integrating medical care, teaching, research, preventive health care, and translational medicine research, and is a provincial high-level hospital built with strong support from the Guangdong Provincial Government and the Zhuhai Municipal Government.

Established in 1971, the Third Affiliated Hospital, Sun Yat-sen University is a comprehensive Grade-A tertiary hospital directly under the National Health Commission. Known for its distinctive strengths, the hospital is renowned at home and abroad for "treating liver diseases, treating brain diseases, and treating complex and critical conditions." It operates four campuses — Tianhe, Luogang, East Guangdong, and Zhaoqing — forming a "one body, two wings; three cities, four campuses" development layout. As an output unit for national regional medical center construction, the hospital ranks at the national frontier in hepatology (liver transplantation, treatment of severe hepatitis), encephalopathy (childhood autism, minimally invasive spine surgery, neuroimmunology), and immune-related diseases. It has 5 national key disciplines (general surgery, endocrinology, neurology, nephrology, and otolaryngology) and 13 national key clinical specialty construction projects.

Founded in 1835, the Sun Yat-sen Memorial Hospital (the Second Affiliated Hospital of Sun Yat-sen University) is the first Western-medicine hospital in China and the cradle of Western medical education in China, where Dr. Sun Yat-sen studied medicine and began his revolutionary activities. The hospital has grown into a large comprehensive Grade-A tertiary hospital integrating medical care, teaching, research, and preventive health care. Its overall strength consistently ranks among the top in China, and it is internationally leading in fields such as tumor microenvironment and RNA medicine, with world-leading techniques including breast-conserving surgery and minimally invasive treatment of urological tumors. The hospital has 9 national key disciplines and 26 national key clinical specialties.